Stereo & Electronics - new speakers installed problems help

i replace all 6 speakers in my 2000 ss, and when the car is off they sound real good, but when i turn the car on, the front ones in the doors start getting static in it, but if turn the car off they sound good and the static goes away, what could be causing this and how do i fix it thanks

Is the car 100% stock? Monsoon amp, deck, and replacing original monsoon speakers?

Is it static or a whine - does the sound vary with engine rpm?

check your wires youre probably making contact some where, or your ground is not good